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In models of mouse melanoma tumors, animals with Beclin-1 (+/−) showed a more aggressive tumor growth and increased angiogenic activity, compared to mice with Beclin-1 wild-type, by boosting the protein expression and stability of hypoxia-inducible factor-2α (HIF-2α) (250)

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Proc Natl Acad Sci U S A (2006) 103:3887–9.10.1073/pnas.0511321103 91 HaraMRSnyderSH