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After introducing a de novo functionalizable strand to a known binding motif and stabilizing the whole sequence via thioether-mediated HBS, they could show a roughly 10-fold increase in potency compared to the linear analogues (Figure 4F)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, et al