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Not only is the acetaldehyde intermediate responsible for the notorious Asian flush reaction and other unpleasant effects, which discourage ethanol ingestion, but the ALDH2 mutation has also been associated with an increased risk of gastrointestinal, esophageal, colon, and liver cancers 20 as well as late-onset Alzheimer’s disease, 21 even in the absence of long-term ethanol usage

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