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Recent studies demonstrated that deletion of promotes PT cell survival and reduces TIF progression in two models of CKD by promoting cell survival and β-catenin activation, leading to reduced tubular injury (atrophy, dilatation, and flattening) and fibrosis (increased collagen accumulation) (Figure 2) [18]
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Conversely, some studies show that a deficiency in vitamin B12 may cause appetite loss, potentially leading to weight loss if left untreated ( If you’re low or deficient in B12, your healthcare provider will likely recommend oral vitamin B12 supplements or injections to increase your blood levels ( summary Low levels of vitamin B12 can cause megaloblastic anemia, which is characterized by shortness of breath, headaches, and fatigue
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