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Specifically, in the case of Alzheimer’s disease, the recruited cells are characterized by inflammatory cytokine gene expression, including Il6 , Tnfa , and Il1b , and thus are called disease inflammatory macrophages (DIMs) [24]
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Substrates for these enzymes are drugs and xenobiotics, including warfarin , aflatoxin, adriamycin, chloramphenicol, and dimethylsulfoxide
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