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In DR models, the copper chaperone COX17 is downregulated under high-glucose conditions, and its overexpression preserves mitochondrial function and reduces retinal injury 188

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(10) reported that l-theanine (500 µM) attenuated neuronal cell death induced by neurotoxins such as rotenone and dieldrin, which are considered as potential environmental pathogens of Parkinson’s disease, in human dopaminergic SH-SY5Y cells, suggesting its direct detoxicating effects on neuronal cells