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In response to genotoxic stress, the uridine of tRNAs that encode lysine, glutamine, and glutamic acid is modified to enhance the wobble of the third position for less exact base pairing in translation, allowing base-pair mutated transcripts to be translated [2,137]

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Methionine contributes to the production of glutathione via its transsulfuration to cysteine [176] and elevated glutathione has also been implicated in the development of drug resistance [17]