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Continuing this trend, another ruthenium compound, named complex-6, was shown to activate caspase-9 in dose- and time-dependent manner, along with up-regulation of BAX and cleaved-caspase-3, and downregulation of Bcl-2 in NCI-H460 lung cancer cells
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[DOI] [PubMed] [Google Scholar] 28.Ayoub KF, Pothineni NVK, Rutland J, Ding Z, Mehta JL