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While modern medications, such as combined oral contraceptives (COCs) for hyperandrogenism and metformin for insulin resistance, effectively target specific symptoms, they often come with limitations, including side effects like gastrointestinal issues from metformin and COCs (95), as well as an incomplete understanding of the complexities of PCOS, particularly concerning gut dysbiosis

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However, many patients discover their actual out-of-pocket costs (deductible + copay + prior authorization delays) exceed PlexusDx's flat-rate model over a 6- to 12-month period