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Pharmacological ablation of astrocytes disrupts the ability of orexin neurons to respond to glucose concentration changes, as orexin neurons rely on astrocyte - derived lactate
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The alternative cofactor Ξ³-Glu-Cys, which is lacking glycine, shows 6.5-fold lower catalytic efficiency than glutathione in the isomerization of 5-AD catalyzed by EcaGST A3-3 (LindstrΓΆm et al., 2018)
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