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Introduction Cognitive decline may occur for a variety of reasons, including the accumulation of senescent cells, 1 excessive oxidative stress, 2 mitochondrial dysfunction, 3 loss of apoptosis, 4 environmental toxins 5,6 depletion of stem cells, 7 telomere shortening, 8 inefficient cell communication, 9 epigenetic alterations 10 and neuroinflammation
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Because platinum drugs do not cross the BBB, the dorsal root ganglia (DRG), involved in somatic and visceral sensitivity, as well as the area postrema (AP), involved in nausea and emesis (see Peripheral Mechanisms in Nausea and Emesis: Unresolved Issues for Exploration ), which are vascularized by fenestrated capillaries, are the main targets of platinum compounds in the nervous system
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