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There is no known upper limit for riboflavin supplementation.[ref] Water-soluble vitamin: Riboflavin is absorbed in the upper small intestine via a riboflavin transporter

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Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue [PMID: 11237704] Laboratory literature summary: Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue