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Although gene–gene and protein–protein interactions are not directly measured in large biobank studies such as the UKB, co-variation of protein abundance is a sufficiently accurate proxy for PPIs because interacting protein pairs are known to be highly co-expressed 37,49

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Some evidence also suggests that a certain dose of indole and its derivatives exert a protective effect, as it reduces the induction of pro-inflammatory cytokines including MCP-1, TNFα, and IL1β