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Step 3, Phase II proof-of-concept: Randomized placebo-controlled trial in 80 to 200 subjects with metabolic disease, measuring fat mass by DEXA, insulin sensitivity by gold-standard clamp or IVGTT, and safety over 12 to 24 weeks
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Conversely, MYC-driven liver tumors upregulated GLS and SLC1A5 and avidly consumed and catabolized glutamine 173, 177 (Figure 8)
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