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In conclusion, this randomized, placebo-controlled phase 1 study has demonstrated that TLC-2716 (a liver- and gut-restricted oral LXR inverse agonist) is safe and well tolerated and produces substantial improvements in plasma lipid metabolism

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The formation of supercomplexes can significantly increase the efficiency of the OXPHOS system by optimizing the utilization of ETS substrates, stabilizing complex I and reducing the formation of ROS [109,110]