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243 In addition, the lncRNA SPRY4 intronic transcript 1 (SPRY4-IT1) similarly enhanced the intestinal epithelial barrier function through augmenting the expression of mRNAs encoding CLDN1, CLDN3, and JAM-1
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Ramos emphasizes is that this is not a single wall but a layered defense system : a physical barrier (tight junctions and epithelial integrity), a chemical barrier (mucus, enzymes, and stomach acid), a microbial barrier (the gut microbiota acting as an immune modulator), and an immune barrier (the gut-associated lymphoid tissue, or GALT)
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