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At the level of intestinal barrier repair, a study conducted in 2015 revealed that the Chang ‘an II Formula comprising Saposhnikovia divaricata (Turcz.) Schischk., Paeonia lactiflora Pall., Atractylodes macrocephala Koidz., Astragalus membranaceus (Fisch.) Bunge, mitigates intestinal mucosal inflammation, repairs the mucosal barrier, and reverses the effects in post-infectious IBS (PI-IBS) model rats, which included conditions such as early sibling deprivation, restraint, and rectal administration of TNBS

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Talanta 74 , 1511–1519 (2008)