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Delving into the sophisticated modalities by which catalase modulates oxidative stress responses is fundamental for formulating precise therapeutic strategies to bolster cellular resilience and avert diseases attributed to oxidative damage [31]
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The available mechanistic in vitro information about the P450 and P-gp inhibitory effects of kratom and the clinical pharmacokinetics of key kratom alkaloids using a well characterized product can be used to develop robust PBPK models
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