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Genetically predetermined deficiencies of the two B12 transport proteins, congenital trans­cobalamin deficiency (gene locus 22q11.2-qter) or hapto­corrin deficiency (gene locus 11q11-q12), can be associated with total serum B12 values that may be normal, or falsely low, respectively (Amos et al., 1994)

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For fertility purposes, this combination provides both direct testicular stimulation (HCG) and increased pituitary support (clomiphene)