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NFκB activation is under the regulation of a loop represented by the clock genes BMAL1/CLOCK, and their transcriptional positive and negative regulators REV-ERBα and RORα ( + levels and silent information regulator type 1 (SIRT1) deacetylase activity, which in turn inactivates NFκB and reduces its binding ability to DNA ( + dissociation and impedes SIRT1-dependent p65 subunit inhibition by deacetylation, resulting in enhanced NFκB transcriptional activity ( On the other hand, NFκB also participates in the regulation of circadian proteins and circadian function